Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human CellsClick to copy article linkArticle link copied!
Abstract

Silver nanoparticles (Ag-np) are being used increasingly in wound dressings, catheters, and various household products due to their antimicrobial activity. The toxicity of starch-coated silver nanoparticles was studied using normal human lung fibroblast cells (IMR-90) and human glioblastoma cells (U251). The toxicity was evaluated using changes in cell morphology, cell viability, metabolic activity, and oxidative stress. Ag-np reduced ATP content of the cell caused damage to mitochondria and increased production of reactive oxygen species (ROS) in a dose-dependent manner. DNA damage, as measured by single cell gel electrophoresis (SCGE) and cytokinesis blocked micronucleus assay (CBMN), was also dose-dependent and more prominent in the cancer cells. The nanoparticle treatment caused cell cycle arrest in G2/M phase possibly due to repair of damaged DNA. Annexin-V propidium iodide (PI) staining showed no massive apoptosis or necrosis. The transmission electron microscopic (TEM) analysis indicated the presence of Ag-np inside the mitochondria and nucleus, implicating their direct involvement in the mitochondrial toxicity and DNA damage. A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage. It is anticipated that DNA damage is augmented by deposition, followed by interactions of Ag-np to the DNA leading to cell cycle arrest in the G2/M phase. The higher sensitivity of U251 cells and their arrest in G2/M phase could be explored further for evaluating the potential use of Ag-np in cancer therapy.
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(3)
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(10)
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(39)
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(10)
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(11)
, 4540-4553. https://doi.org/10.1021/acs.iecr.2c01327
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(9)
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(46)
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(35)
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(8)
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(7)
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(7)
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(23)
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(22)
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(5)
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(9)
, 5706-5713. https://doi.org/10.1021/acs.est.1c08246
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(3)
, 4350-4359. https://doi.org/10.1021/acsanm.2c00119
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(8)
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(5)
, 1863-1870. https://doi.org/10.1021/acssuschemeng.1c07368
- Ronggang Liu, Kangjing Liu, Guoxin Cui, Mingqian Tan. Change of Cell Toxicity of Food-Borne Nanoparticles after Forming Protein Coronas with Human Serum Albumin. Journal of Agricultural and Food Chemistry 2022, 70
(4)
, 1261-1271. https://doi.org/10.1021/acs.jafc.1c06814
- Danielle F. Mello, Laura L. Maurer, Ian T. Ryde, Dong Hoon Songr, Stella M. Marinakos, Chuanjia Jiang, Mark R. Wiesner, Heileen Hsu-Kim, Joel N. Meyer. In Vivo Effects of Silver Nanoparticles on Development, Behavior, and Mitochondrial Function are Altered by Genetic Defects in Mitochondrial Dynamics. Environmental Science & Technology 2022, 56
(2)
, 1113-1124. https://doi.org/10.1021/acs.est.1c05915
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(33)
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- Amjed Alabresm, Savannah L. Chandler, Brian C. Benicewicz, Alan W. Decho. Nanotargeting of Resistant Infections with a Special Emphasis on the Biofilm Landscape. Bioconjugate Chemistry 2021, 32
(8)
, 1411-1430. https://doi.org/10.1021/acs.bioconjchem.1c00116
- Shiyao Li, Yi Ju, Jiajing Zhou, Ka Fung Noi, Andrew J. Mitchell, Tian Zheng, Stephen J. Kent, Christopher J. H. Porter, Frank Caruso. Quantitatively Tracking Bio–Nano Interactions of Metal–Phenolic Nanocapsules by Mass Cytometry. ACS Applied Materials & Interfaces 2021, 13
(30)
, 35494-35505. https://doi.org/10.1021/acsami.1c09406
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(7)
, 7295-7308. https://doi.org/10.1021/acsanm.1c01276
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(28)
, 18260-18268. https://doi.org/10.1021/acsomega.1c02149
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(5)
, 8363-8375. https://doi.org/10.1021/acsnano.0c10150
- Berhanu Zewde, Olufolasade Atoyebi, Ayele Gugssa, Karen J. Gaskell, Dharmaraj Raghavan. An Investigation of the Interaction between Bovine Serum Albumin-Conjugated Silver Nanoparticles and the Hydrogel in Hydrogel Nanocomposites. ACS Omega 2021, 6
(17)
, 11614-11627. https://doi.org/10.1021/acsomega.1c00834
- Xingjuan Zhao, Shirley Campbell, Patrick Z. El-Khoury, Yuechen Jia, Gregory Q. Wallace, Audrey Claing, C. Geraldine Bazuin, Jean-Francois Masson. Surface-Enhanced Raman Scattering Optophysiology Nanofibers for the Detection of Heavy Metals in Single Breast Cancer Cells. ACS Sensors 2021, 6
(4)
, 1649-1662. https://doi.org/10.1021/acssensors.1c00332
- Olena Ivashchenko, Łucja Przysiecka, Barbara Peplińska, Dorota Flak, Emerson Coy, Marcin Jarek, Tomasz Zalewski, Andrzej Musiał, Stefan Jurga. Organic–Inorganic Hybrid Nanoparticles Synthesized with Hypericum perforatum Extract: Potential Agents for Photodynamic Therapy at Ultra-low Power Light. ACS Sustainable Chemistry & Engineering 2021, 9
(4)
, 1625-1645. https://doi.org/10.1021/acssuschemeng.0c07036
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(10)
, 12341-12369. https://doi.org/10.1021/acsnano.0c05937
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(10)
, 2605-2622. https://doi.org/10.1021/acs.chemrestox.0c00250
- Alexander Urstoeger, Andreas Wimmer, Ralf Kaegi, Simon Reiter, Michael Schuster. Looking at Silver-Based Nanoparticles in Environmental Water Samples: Repetitive Cloud Point Extraction Bridges Gaps in Electron Microscopy for Naturally Occurring Nanoparticles. Environmental Science & Technology 2020, 54
(19)
, 12063-12071. https://doi.org/10.1021/acs.est.0c02878
- Neng Yan, Synn Man Jennifer Tsim, Xuewen He, Ben Zhong Tang, Wen-Xiong Wang. Direct Visualization and Quantification of Maternal Transfer of Silver Nanoparticles in Zooplankton. Environmental Science & Technology 2020, 54
(17)
, 10763-10771. https://doi.org/10.1021/acs.est.0c03228
- Qiang Zhang, Han Wen, Kiri Watanabe, Ibuki Kotani, Monica Ricci, Beatrice Fortuni, Anh Thi Ngoc Dao, Akito Masuhara, Kenji Hirai, Hitoshi Kasai, Tomoko Inose, Hiroshi Uji-i. Low-Cytotoxic Gold-Coated Silver Nanoflowers for Intracellular pH Sensing. ACS Applied Nano Materials 2020, 3
(8)
, 7643-7650. https://doi.org/10.1021/acsanm.0c01278
- Junjie Xu, Kai Zhu, Yanglong Hou. Magnetic Heterostructures: Interface Control to Optimize Magnetic Property and Multifunctionality. ACS Applied Materials & Interfaces 2020, 12
(33)
, 36811-36822. https://doi.org/10.1021/acsami.0c09934
- Jaehee Jang, Jong-Min Lee, Sang-Bin Oh, Yonghyun Choi, Han-Sung Jung, Jonghoon Choi. Development of Antibiofilm Nanocomposites: Ag/Cu Bimetallic Nanoparticles Synthesized on the Surface of Graphene Oxide Nanosheets. ACS Applied Materials & Interfaces 2020, 12
(32)
, 35826-35834. https://doi.org/10.1021/acsami.0c06054
- Ali Sedighi, Ramezan Ali Taheri, Majid Montazer. High-Performance Electromagnetic Interference Shielding Electrodes/Substrates for Wearable Electronics. Industrial & Engineering Chemistry Research 2020, 59
(28)
, 12774-12783. https://doi.org/10.1021/acs.iecr.0c02141
- Xiaolu Zhuo, Malou Henriksen-Lacey, Dorleta Jimenez de Aberasturi, Ana Sánchez-Iglesias, Luis M. Liz-Marzán. Shielded Silver Nanorods for Bioapplications. Chemistry of Materials 2020, 32
(13)
, 5879-5889. https://doi.org/10.1021/acs.chemmater.0c01995
- Chaturanga D. Bandara, Giulia Ballerin, Miika Leppänen, Tuquabo Tesfamichael, Kostya Ken Ostrikov, Cynthia B. Whitchurch. Resolving Bio–Nano Interactions of E. coli Bacteria–Dragonfly Wing Interface with Helium Ion and 3D-Structured Illumination Microscopy to Understand Bacterial Death on Nanotopography. ACS Biomaterials Science & Engineering 2020, 6
(7)
, 3925-3932. https://doi.org/10.1021/acsbiomaterials.9b01973
- Yi Deng, Xiuyuan Shi, Yong Chen, Weizhong Yang, Yuan Ma, Xiao-Lei Shi, Pingan Song, Matthew S. Dargusch, Zhi-Gang Chen. Bacteria-Triggered pH-Responsive Osteopotentiating Coating on 3D-Printed Polyetheretherketone Scaffolds for Infective Bone Defect Repair. Industrial & Engineering Chemistry Research 2020, 59
(26)
, 12123-12135. https://doi.org/10.1021/acs.iecr.0c02107
- Shaoshan Huang, Huiling Liu, Kedan Liao, Qinqin Hu, Rui Guo, Kaixian Deng. Functionalized GO Nanovehicles with Nitric Oxide Release and Photothermal Activity-Based Hydrogels for Bacteria-Infected Wound Healing. ACS Applied Materials & Interfaces 2020, 12
(26)
, 28952-28964. https://doi.org/10.1021/acsami.0c04080
- Balam Ruiz-Ruiz, María Evarista Arellano-García, Patricia Radilla-Chávez, David Sergio Salas-Vargas, Yanis Toledano-Magaña, Francisco Casillas-Figueroa, Roberto Luna Vazquez-Gomez, Alexey Pestryakov, Juan Carlos García-Ramos, Nina Bogdanchikova. Cytokinesis-Block Micronucleus Assay Using Human Lymphocytes as a Sensitive Tool for Cytotoxicity/Genotoxicity Evaluation of AgNPs. ACS Omega 2020, 5
(21)
, 12005-12015. https://doi.org/10.1021/acsomega.0c00149
- Berkay Ozcelik, Paul Pasic, Parveen Sangwan, Cheang Ly Be, Veronica Glattauer, Helmut Thissen, Ramiz A. Boulos. Evaluation of the Novel Antimicrobial BCP3 in a Coating for Endotracheal Tubes. ACS Omega 2020, 5
(18)
, 10288-10296. https://doi.org/10.1021/acsomega.9b04178
- Varvara Gribova, Fouzia Boulmedais, Agnès Dupret-Bories, Cynthia Calligaro, Bernard Senger, Nihal Engin Vrana, Philippe Lavalle. Polyanionic Hydrogels as Reservoirs for Polycationic Antibiotic Substitutes Providing Prolonged Antibacterial Activity. ACS Applied Materials & Interfaces 2020, 12
(17)
, 19258-19267. https://doi.org/10.1021/acsami.9b23140
- Qing Zhong, Hui Long, Wei Hu, Liujun Shi, Fei Zan, Meng Xiao, Shaozao Tan, Yu Ke, Gang Wu, Huifang Chen. Dual-Function Antibacterial Micelle via Self-Assembling Block Copolymers with Various Antibacterial Nanoparticles. ACS Omega 2020, 5
(15)
, 8523-8533. https://doi.org/10.1021/acsomega.9b04086
- Sukanya Srijampa, Surachat Buddhisa, Sawinee Ngernpimai, Chanvit Leelayuwat, Siriporn Proungvitaya, Apiwat Chompoosor, Patcharaporn Tippayawat. Influence of Gold Nanoparticles with Different Surface Charges on Localization and Monocyte Behavior. Bioconjugate Chemistry 2020, 31
(4)
, 1133-1143. https://doi.org/10.1021/acs.bioconjchem.9b00847
- Alessandro L. Urzedo, Marcelly C. Gonçalves, Mônica H. M. Nascimento, Christiane B. Lombello, Gerson Nakazato, Amedea B. Seabra. Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications. ACS Biomaterials Science & Engineering 2020, 6
(4)
, 2117-2134. https://doi.org/10.1021/acsbiomaterials.9b01685
- Lee Schnaider, Zenon Toprakcioglu, Assaf Ezra, Xizhou Liu, Darya Bychenko, Aviad Levin, Ehud Gazit, Tuomas P. J. Knowles. Biocompatible Hybrid Organic/Inorganic Microhydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo. Nano Letters 2020, 20
(3)
, 1590-1597. https://doi.org/10.1021/acs.nanolett.9b04290
- Sebastian Jusuf, Jie Hui, Pu-Ting Dong, Ji-Xin Cheng. Staphyloxanthin Photolysis Potentiates Low Concentration Silver Nanoparticles in Eradication of Methicillin-Resistant Staphylococcus aureus. The Journal of Physical Chemistry C 2020, 124
(9)
, 5321-5330. https://doi.org/10.1021/acs.jpcc.9b10209
- Sami Rtimi, Stephanos Konstantinidis, Nikolay Britun, Victor Nadtochenko, Inessa Khmel, John Kiwi. New Evidence for Ag-Sputtered Materials Inactivating Bacteria by Surface Contact without the Release of Ag Ions: End of a Long Controversy?. ACS Applied Materials & Interfaces 2020, 12
(4)
, 4998-5007. https://doi.org/10.1021/acsami.9b15859
- Vrushali B. Shevale, Ananta G. Dhodamani, Sagar D. Delekar. Catalytic Reclamation of Silver Present in Photographic Waste Using Magnetically Separable TiO2@CuFe2O4 Nanocomposites and Thereof Its Use in Antibacterial Activity. ACS Omega 2020, 5
(2)
, 1098-1108. https://doi.org/10.1021/acsomega.9b03260
- . Sustainability & Green Polymer Chemistry Volume 1: Green Products and Processes. 2020https://doi.org/10.1021/bk-2020-1372
- Jun Akimoto Yoshihiro Ito . Thermoresponsive Biodegradable Polymeric Materials for Biomedical Application. 2020, 159-172. https://doi.org/10.1021/bk-2020-1372.ch009
- Zhiqiang Tan, Xiaoru Guo, Yongguang Yin, Bowen Wang, Qingsheng Bai, Xia Li, Jingfu Liu, Guibin Jiang. Freezing Facilitates Formation of Silver Nanoparticles under Natural and Simulated Sunlight Conditions. Environmental Science & Technology 2019, 53
(23)
, 13802-13811. https://doi.org/10.1021/acs.est.9b05926
- Janan Hui, Zachary J. O’Dell, Arka Rao, Kathryn R. Riley. In Situ Quantification of Silver Nanoparticle Dissolution Kinetics in Simulated Sweat Using Linear Sweep Stripping Voltammetry. Environmental Science & Technology 2019, 53
(22)
, 13117-13125. https://doi.org/10.1021/acs.est.9b04151
- Jiya Jose, Abdulaziz Anas, Bina Jose, Anand B. Puthirath, Sujith Athiyanathil, Chekidhenkuzhiyil Jasmin, M. R. Anantharaman, Shanta Nair, Challapalli Subrahmanyam, Vasudevanpillai Biju. Extinction of Antimicrobial Resistant Pathogens Using Silver Embedded Silica Nanoparticles and an Efflux Pump Blocker. ACS Applied Bio Materials 2019, 2
(11)
, 4681-4686. https://doi.org/10.1021/acsabm.9b00614
- Tao-Ho Chang, Yung-Wen Liu, Ying-Hong Lin, Jiang-Jen Lin, Jenn-Wen Huang, Adil Hussain, Pi-Fang Linda Chang. Silver Nanoparticles on Nanoscale Silica Platelets (AgNP/NSP) and Nanoscale Silica Platelets (NSP) Inhibit the Development of Fusarium oxysporum f. sp. niveum. ACS Applied Bio Materials 2019, 2
(11)
, 4978-4985. https://doi.org/10.1021/acsabm.9b00699
- Masaya Shimabukuro, Yusuke Tsutsumi, Risa Yamada, Maki Ashida, Peng Chen, Hisashi Doi, Kosuke Nozaki, Akiko Nagai, Takao Hanawa. Investigation of Realizing Both Antibacterial Property and Osteogenic Cell Compatibility on Titanium Surface by Simple Electrochemical Treatment. ACS Biomaterials Science & Engineering 2019, 5
(11)
, 5623-5630. https://doi.org/10.1021/acsbiomaterials.8b01058
- Zhen Wu, Youliang Hong. Combination of the Silver–Ethylene Interaction and 3D Printing To Develop Antibacterial Superporous Hydrogels for Wound Management. ACS Applied Materials & Interfaces 2019, 11
(37)
, 33734-33747. https://doi.org/10.1021/acsami.9b14090
- Jitendra Pant, Shriya Pedaparthi, Sean P. Hopkins, Marcus J. Goudie, Megan E. Douglass, Hitesh Handa. Antibacterial and Cellular Response Toward a Gasotransmitter-Based Hybrid Wound Dressing. ACS Biomaterials Science & Engineering 2019, 5
(8)
, 4002-4012. https://doi.org/10.1021/acsbiomaterials.9b00737
- Guangxin Duan, Lu Chen, Zhifeng Jing, Phil De Luna, Ling Wen, Leili Zhang, Lin Zhao, Jiaying Xu, Zhen Li, Zaixing Yang, Ruhong Zhou. Robust Antibacterial Activity of Tungsten Oxide (WO3-x) Nanodots. Chemical Research in Toxicology 2019, 32
(7)
, 1357-1366. https://doi.org/10.1021/acs.chemrestox.8b00399
- Serenella Medici, Massimiliano Peana, Valeria M. Nurchi, Maria Antonietta Zoroddu. Medical Uses of Silver: History, Myths, and Scientific Evidence. Journal of Medicinal Chemistry 2019, 62
(13)
, 5923-5943. https://doi.org/10.1021/acs.jmedchem.8b01439
- Wensi Chen, Jinyue Jiang, Wenlong Zhang, Ting Wang, Jianfeng Zhou, Ching-Hua Huang, Xing Xie. Silver Nanowire-Modified Filter with Controllable Silver Ion Release for Point-of-Use Disinfection. Environmental Science & Technology 2019, 53
(13)
, 7504-7512. https://doi.org/10.1021/acs.est.9b01678
- Po-Hsuan Hsiao, Chia-Yun Chen. Insights for Realizing Ultrasensitive Colorimetric Detection of Glucose Based on Carbon/Silver Core/Shell Nanodots. ACS Applied Bio Materials 2019, 2
(6)
, 2528-2538. https://doi.org/10.1021/acsabm.9b00228
- Megan
E. Douglass, Marcus J. Goudie, Jitendra Pant, Priyadarshini Singha, Sean Hopkins, Ryan Devine, Chad W. Schmiedt, Hitesh Handa. Catalyzed Nitric Oxide Release via Cu Nanoparticles Leads to an Increase in Antimicrobial Effects and Hemocompatibility for Short-Term Extracorporeal Circulation. ACS Applied Bio Materials 2019, 2
(6)
, 2539-2548. https://doi.org/10.1021/acsabm.9b00237
- Congyang Mao, Yiming Xiang, Xiangmei Liu, Yufeng Zheng, Kelvin Wai Kwok Yeung, Zhenduo Cui, Xianjin Yang, Zhaoyang Li, Yanqin Liang, Shengli Zhu, Shuilin Wu. Local Photothermal/Photodynamic Synergistic Therapy by Disrupting Bacterial Membrane To Accelerate Reactive Oxygen Species Permeation and Protein Leakage. ACS Applied Materials & Interfaces 2019, 11
(19)
, 17902-17914. https://doi.org/10.1021/acsami.9b05787
- Rachel Foulkes, Mohsen Ali Asgari, Anthony Curtis, Clare Hoskins. Silver-Nanoparticle-Mediated Therapies in the Treatment of Pancreatic Cancer. ACS Applied Nano Materials 2019, 2
(4)
, 1758-1772. https://doi.org/10.1021/acsanm.9b00439
- Rushikesh
S. Ambekar, Balasubramanian Kandasubramanian. Progress in the Advancement of Porous Biopolymer Scaffold: Tissue Engineering Application. Industrial & Engineering Chemistry Research 2019, 58
(16)
, 6163-6194. https://doi.org/10.1021/acs.iecr.8b05334
- Junfang Zhang, Jiachao Xu, Haijun Ma, Haotian Bai, Libing Liu, Chunying Shu, Hui Li, Shu Wang, Chunru Wang. Designing an Amino-Fullerene Derivative C70–(EDA)8 to Fight Superbacteria. ACS Applied Materials & Interfaces 2019, 11
(16)
, 14597-14607. https://doi.org/10.1021/acsami.9b01483
- Yuan Dong, Shuangshuang Chen, Xuemin Lu, Qinghua Lu. High-Level Extraction of Recyclable Nanocatalysts by Using Polyphosphazene Microparticles. Langmuir 2019, 35
(15)
, 5168-5175. https://doi.org/10.1021/acs.langmuir.9b00258
- Yun Chang, Yan Cheng, Yanlin Feng, Kai Li, Hui Jian, Haiyuan Zhang. Upshift of the d Band Center toward the Fermi Level for Promoting Silver Ion Release, Bacteria Inactivation, and Wound Healing of Alloy Silver Nanoparticles. ACS Applied Materials & Interfaces 2019, 11
(13)
, 12224-12231. https://doi.org/10.1021/acsami.8b21768
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