Toxic Effects of Levamisole in a Cocaine User
Published June 16, 2011
N Engl J Med 2011;364: e52
DOI: 10.1056/NEJMicm1008722
Abstract
A 54-year-old woman presented with a 2-day history of a painful, enlarging rash over her face (Panel A), ears (Panel B), breasts, and extremities. Laboratory studies revealed neutropenia (neutrophil count, 1070 per cubic millimeter) and lymphopenia (lymphocyte count, 680 per cubic millimeter); the detection of antineutrophil cytoplasmic antibodies (ANCA) by immunofluorescence testing showed the perinuclear pattern (p-ANCA) and the cytoplasmic pattern (c-ANCA), and an enzyme-linked immunosorbent assay revealed a proteinase-3 antibody titer of 1:320. Toxicologic screening of the urine was positive for cocaine and opiates. The urine levamisole level 2 days after admission was positive at 920 ng per milliliter. . . .
Information & Authors
Information
Published In
Copyright
Copyright © 2011 Massachusetts Medical Society. All rights reserved.
For personal use only. Any commercial reuse of NEJM Group content requires permission.
History
Published online: June 16, 2011
Published in issue: June 16, 2011
Topics
Authors
Affiliations
Henry Ford Hospital, Detroit, MI
[email protected]
[email protected]
Metrics & Citations
Metrics
Altmetrics
Citations
Export citation
Select the format you want to export the citation of this publication.
Cited by
- Inherent Dangers of Using Non–US Food and Drug Administration–Approved Substances of Abuse, The Journal of Clinical Pharmacology, 61, S2, (2021).https://doi.org/10.1002/jcph.1860
- Facial angioedema in young elderly: Rare complication of rare drug, Annals of Geriatric Education and Medical Sciences, 8, 1, (22-24), (2021).https://doi.org/10.18231/j.agems.2021.006
- The Rapidly Changing Composition of the Global Street Drug Supply and its Effects on High-risk Groups for COVID-19, Current Psychopharmacology, 10, 2, (138-154), (2021).https://doi.org/10.2174/2211556010666210125124645
- Levamisole—a Toxic Adulterant in Illicit Drug Preparations: a Review, Therapeutic Drug Monitoring, 43, 2, (221-228), (2021).https://doi.org/10.1097/FTD.0000000000000851
- Is Cocaine Coming Back? A Commentary, Substance Use & Misuse, 55, 2, (345-348), (2019).https://doi.org/10.1080/10826084.2019.1664592
- Novel Drugs of Abuse, Pediatrics In Review, 40, 2, (71-78), (2019).https://doi.org/10.1542/pir.2018-0050
- Determination of cutting agents in seized cocaine samples using GC–MS, GC–TMS and LC–MS/MS, Forensic Science International, 295, (199-206), (2019).https://doi.org/10.1016/j.forsciint.2018.12.016
- Anatomical Findings, Postmortem Toxicology, (59-77), (2019).https://doi.org/10.1016/B978-0-12-815163-1.00006-X
- Detection of Cutting Agents in Drug‐Positive Seized Exhibits within the United States, Journal of Forensic Sciences, 64, 3, (888-896), (2018).https://doi.org/10.1111/1556-4029.13968
- DARK Classics in Chemical Neuroscience: Aminorex Analogues, ACS Chemical Neuroscience, 9, 10, (2484-2502), (2018).https://doi.org/10.1021/acschemneuro.8b00415
- See more
Loading...
