CT angiography is an exciting yet controversial application of helical (spiral) CT technology. Although many radiologists equate CT angiography with three-dimensional (3D) rendering, we believe that axial images, multiplanar reformatted (MPR) images, and true 3D models all contribute to a better evaluation of the vascular system than was possible with conventional CT. This occurs because helical scans are volumetric and are accomplished rapidly with high levels of circulating contrast material. This article reviews the indications for CT angiography, compares CT angiography with other techniques, and offers a practical methodology for neuroradiologic, thoracic, and abdominal applications of CT angiography.