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. 2008 Jan;32(1):67-77.
doi: 10.1016/j.compmedimag.2007.09.004.

CT-perfusion imaging of the human brain: advanced deconvolution analysis using circulant singular value decomposition

H J Wittsack  1 , A M Wohlschläger, E K Ritzl, R Kleiser, M Cohnen, R J Seitz, U Mödder
Affiliations

CT-perfusion imaging of the human brain: advanced deconvolution analysis using circulant singular value decomposition

H J Wittsack et al. Comput Med Imaging Graph. 2008 Jan.

Abstract

According to indicator dilution theory tissue time-concentration curves have to be deconvolved with arterial input curves in order to get valid perfusion results. Our aim was to adapt and validate a deconvolution method originating from magnetic resonance techniques and apply it to the calculation of dynamic contrast enhanced computed tomography perfusion imaging. The application of a block-circulant matrix approach for singular value decomposition renders the analysis independent of tracer arrival time to improve the results.

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