UC Irvine

Introduction:Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods:Our international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results:This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion:A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

Spin transfer torque magnetic random access memory (STT-MRAM) is a promising candidate for next generation memory as it is non-volatile, fast, and has unlimited endurance. Another important aspect of STT-MRAM is that its core component, the nanoscale magnetic tunneling junction (MTJ), is thought to be radiation hard, making it attractive for space and nuclear technology applications. However, studies of the effects of high doses of ionizing radiation on STT-MRAM writing process are lacking. Here we report measurements of the impact of high doses of gamma and neutron radiation on nanoscale MTJs with perpendicular magnetic anistropy used in STT-MRAM. We characterize the tunneling magnetoresistance, the magnetic field switching, and the current-induced switching before and after irradiation. Our results demonstrate that all these key properties of nanoscale MTJs relevant to STT-MRAM applications are robust against ionizing radiation. Additionally, we perform experiments on thermally driven stochastic switching in the gamma ray environment. These results indicate that nanoscale MTJs are promising building blocks for radiation-hard non-von Neumann computing.

A three-dimensional round liquid jet within a low-speed coaxial gas flow is numerically simulated and explained via vortex dynamics ($\lambda_2$ method). The instabilities on the liquid-gas interface reflect well the vortex interactions around the interface. Certain key features are identified for the first time. Two types of surface deformations are distinguished, which are separated by a large indentation on the jet stem: First, those near the jet start-up cap are encapsulated inside the recirculation zone behind the cap. These deformations are directly related to the dynamics of the growing cap and well explained by the vortices generated there. Second, deformations occurring farther upstream of the cap are mainly driven by the Kelvin-Helmholtz (KH) instability at the interface. Three-dimensional deformations occur in the vortex structures first, and the initially axisymmetric KH vortices deform and lead to several liquid lobes, which stretch first as thinning sheets and then either continue stretching directly into elongated ligaments - at lower relative velocity - or perforate to create liquid bridges and holes - at higher relative velocity. The different scenarios depend on Weber and Reynolds numbers based on the relative gas-liquid velocity as was found in the temporal studies. The deformations in the upstream region are well portrayed in a frame moving with the convective velocity of the liquid jet. The usefulness of the temporal analyses are now established.

Historically in the United States, periods of large-scale immigration have been accompanied by perceptions of threat and stereotypes of the feared criminality of immigrants. A century ago major commissions investigated the connection of immigration to crime; each found lower levels of criminal involvement among the foreign-born. The present period echoes that past. Over the past quarter century, alarms have been raised about large-scale immigration, and especially about undocumented immigrants from Latin America. But over the same period, violent crime and property crime rates have been cut in half; the decline in crime has been more pronounced in cities with larger shares of immigrants; and foreign-born young men are much less likely to be incarcerated than natives. The evidence demonstrating lower levels of criminal involvement among immigrants is supported by a growing number of contemporary studies. At the same time the period has been marked by the criminalization of immigration itself, and by the confluence of immigration and criminal law and enforcement apparatuses. A series of critical events succeeded by moral panics influenced the passage of hyper-restrictive laws and a massive injection of institutional resources that has built the “crimmigration” enforcement apparatus into the “formidable machinery” underpinning mass deportation today.

© 2019 A high precision calibration of the nonlinearity in the energy response of the Daya Bay Reactor Neutrino Experiment's antineutrino detectors is presented in detail. The energy nonlinearity originates from the particle-dependent light yield of the scintillator and charge-dependent electronics response. The nonlinearity model is constrained by γ calibration points from deployed and naturally occurring radioactive sources, the β spectrum from 12B decays, and a direct measurement of the electronics nonlinearity with a new flash analog-to-digital converter readout system. Less than 0.5% uncertainty in the energy nonlinearity calibration is achieved for positrons of kinetic energies greater than 1 MeV.