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Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community. http://feeds.nature.com/nature/rss/current Nature Publishing Group en © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nature/rss.png http://feeds.nature.com/nature/rss/current https://www.nature.com/articles/s41586-025-09692-7 Nature, Published online: 10 October 2025; doi:10.1038/s41586-025-09692-7Author Correction: Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus]]> Qintao WangHonghao ZhuXiangwei SunChangming ZhangShuangyue MaYing JinJinjian FuChenlu LiuJiahui PengRuoran WangLin LiuYi ZengCheng GongQing ZhouXiaomin YuZhihong Liu doi:10.1038/s41586-025-09692-7 Nature, Published online: 2025-10-10; | doi:10.1038/s41586-025-09692-7 2025-10-10 Nature 10.1038/s41586-025-09692-7 https://www.nature.com/articles/s41586-025-09692-7 https://www.nature.com/articles/d41586-025-03244-9 Nature, Published online: 10 October 2025; doi:10.1038/d41586-025-03244-9Genetic analysis reveals that most living genera of mosquitoes emerged around 73 million years ago.]]> doi:10.1038/d41586-025-03244-9 Nature, Published online: 2025-10-10; | doi:10.1038/d41586-025-03244-9 2025-10-10 Nature 10.1038/d41586-025-03244-9 https://www.nature.com/articles/d41586-025-03244-9 https://www.nature.com/articles/d41586-025-03282-3 Nature, Published online: 10 October 2025; doi:10.1038/d41586-025-03282-3Recordings of chewing sounds combined with altitude data bear evidence of a gruesome night-time feast.]]> doi:10.1038/d41586-025-03282-3 Nature, Published online: 2025-10-10; | doi:10.1038/d41586-025-03282-3 2025-10-10 Nature 10.1038/d41586-025-03282-3 https://www.nature.com/articles/d41586-025-03282-3 https://www.nature.com/articles/d41586-025-03245-8 Nature, Published online: 10 October 2025; doi:10.1038/d41586-025-03245-8Laser plasma device could be light enough to be used on the field.]]> doi:10.1038/d41586-025-03245-8 Nature, Published online: 2025-10-10; | doi:10.1038/d41586-025-03245-8 2025-10-10 Nature 10.1038/d41586-025-03245-8 https://www.nature.com/articles/d41586-025-03245-8 https://www.nature.com/articles/d41586-025-03324-w Nature, Published online: 10 October 2025; doi:10.1038/d41586-025-03324-wResearchers warn against ‘top down’ solutions as ceasefire is agreed in the first phase of a peace deal.]]> Michele Catanzaro doi:10.1038/d41586-025-03324-w Nature, Published online: 2025-10-10; | doi:10.1038/d41586-025-03324-w 2025-10-10 Nature 10.1038/d41586-025-03324-w https://www.nature.com/articles/d41586-025-03324-w https://www.nature.com/articles/d41586-025-03251-w Nature, Published online: 10 October 2025; doi:10.1038/d41586-025-03251-wAlone but not lonely.]]> Dandan Peng doi:10.1038/d41586-025-03251-w Nature, Published online: 2025-10-10; | doi:10.1038/d41586-025-03251-w 2025-10-10 Nature 10.1038/d41586-025-03251-w https://www.nature.com/articles/d41586-025-03251-w https://www.nature.com/articles/d41586-025-03280-5 Nature, Published online: 10 October 2025; doi:10.1038/d41586-025-03280-5This class of synthetic opioids is more potent than heroin and morphine.]]> Mohana Basu doi:10.1038/d41586-025-03280-5 Nature, Published online: 2025-10-10; | doi:10.1038/d41586-025-03280-5 2025-10-10 Nature 10.1038/d41586-025-03280-5 https://www.nature.com/articles/d41586-025-03280-5 https://www.nature.com/articles/d41586-025-03332-w Nature, Published online: 10 October 2025; doi:10.1038/d41586-025-03332-wHopes of securing a United Nations treaty on plastic pollution are fading after the final round of negotiations ended without an agreement.]]> Katharine Sanderson doi:10.1038/d41586-025-03332-w Nature, Published online: 2025-10-10; | doi:10.1038/d41586-025-03332-w 2025-10-10 Nature 10.1038/d41586-025-03332-w https://www.nature.com/articles/d41586-025-03332-w https://www.nature.com/articles/d41586-025-03288-x Nature, Published online: 10 October 2025; doi:10.1038/d41586-025-03288-xConservationists debate the pros and cons of using synthetic biology techniques to alter wild species.]]> Mariana Lenharo doi:10.1038/d41586-025-03288-x Nature, Published online: 2025-10-10; | doi:10.1038/d41586-025-03288-x 2025-10-10 Nature 10.1038/d41586-025-03288-x https://www.nature.com/articles/d41586-025-03288-x https://www.nature.com/articles/d41586-025-03279-y Nature, Published online: 09 October 2025; doi:10.1038/d41586-025-03279-yFour subtle changes to an enzyme might explain the hairless rodents’ longevity.]]> Mohana Basu doi:10.1038/d41586-025-03279-y Nature, Published online: 2025-10-09; | doi:10.1038/d41586-025-03279-y 2025-10-09 Nature 10.1038/d41586-025-03279-y https://www.nature.com/articles/d41586-025-03279-y https://www.nature.com/articles/d41586-025-03322-y Nature, Published online: 09 October 2025; doi:10.1038/d41586-025-03322-yThrough fieldwork and innovative research, he transformed how scientists and the public perceive the prehistoric world.]]> Michael J. Novacek doi:10.1038/d41586-025-03322-y Nature, Published online: 2025-10-09; | doi:10.1038/d41586-025-03322-y 2025-10-09 Nature 10.1038/d41586-025-03322-y https://www.nature.com/articles/d41586-025-03322-y https://www.nature.com/articles/d41586-025-03247-6 Nature, Published online: 09 October 2025; doi:10.1038/d41586-025-03247-6The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.]]> Jenna Ahart doi:10.1038/d41586-025-03247-6 Nature, Published online: 2025-10-09; | doi:10.1038/d41586-025-03247-6 2025-10-09 Nature 10.1038/d41586-025-03247-6 https://www.nature.com/articles/d41586-025-03247-6 https://www.nature.com/articles/d41586-025-03299-8 Nature, Published online: 09 October 2025; doi:10.1038/d41586-025-03299-8A blood test has achieved 96% accuracy in diagnosing the condition in a small study of individuals. What does the test detect, and is it a biomarker of the condition?]]> David Adam doi:10.1038/d41586-025-03299-8 Nature, Published online: 2025-10-09; | doi:10.1038/d41586-025-03299-8 2025-10-09 Nature 10.1038/d41586-025-03299-8 https://www.nature.com/articles/d41586-025-03299-8 https://www.nature.com/articles/d41586-025-02681-w Nature, Published online: 09 October 2025; doi:10.1038/d41586-025-02681-wBy refusing to bend the rules I set for myself, I created structure and a better environment for my mental health.]]> Jasmine Gabriel Hughes doi:10.1038/d41586-025-02681-w Nature, Published online: 2025-10-09; | doi:10.1038/d41586-025-02681-w 2025-10-09 Nature 10.1038/d41586-025-02681-w https://www.nature.com/articles/d41586-025-02681-w https://www.nature.com/articles/d41586-025-03337-5 Nature, Published online: 09 October 2025; doi:10.1038/d41586-025-03337-5A group of neurons in mice stay active long after an initial pain response. Plus, how AI agents might change research and the winners of this year’s ‘genius grants’.]]> Jacob Smith doi:10.1038/d41586-025-03337-5 Nature, Published online: 2025-10-09; | doi:10.1038/d41586-025-03337-5 2025-10-09 Nature 10.1038/d41586-025-03337-5 https://www.nature.com/articles/d41586-025-03337-5 https://www.nature.com/articles/d41586-025-02899-8 Nature, Published online: 09 October 2025; doi:10.1038/d41586-025-02899-8Funding crises, bereavement and a supervisor’s relocation can derail your career path, but you can overcome them.]]> Julie Gould doi:10.1038/d41586-025-02899-8 Nature, Published online: 2025-10-09; | doi:10.1038/d41586-025-02899-8 2025-10-09 Nature 10.1038/d41586-025-02899-8 https://www.nature.com/articles/d41586-025-02899-8 https://www.nature.com/articles/s41586-025-09697-2 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09697-2Enzyme specificity prediction using cross attention graph neural networks]]> Haiyang CuiYufeng SuTanner J. DeanTianhao YuZhengyi ZhangJian PengDiwakar ShuklaHuimin Zhao doi:10.1038/s41586-025-09697-2 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09697-2 2025-10-08 Nature 10.1038/s41586-025-09697-2 https://www.nature.com/articles/s41586-025-09697-2 https://www.nature.com/articles/d41586-025-03298-9 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03298-9Images from across the web portray women as being younger than men, despite the underlying reality — plus, astronomers’ favourite exoplanets, and the 2025 Nobel prizes.]]> Benjamin ThompsonNick Petrić Howe doi:10.1038/d41586-025-03298-9 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03298-9 2025-10-08 Nature 10.1038/d41586-025-03298-9 https://www.nature.com/articles/d41586-025-03298-9 https://www.nature.com/articles/d41586-025-03270-7 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03270-7DNA found in fossils from southwestern Germany suggests the populations survived in the region much longer than expected.]]> doi:10.1038/d41586-025-03270-7 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03270-7 2025-10-08 Nature 10.1038/d41586-025-03270-7 https://www.nature.com/articles/d41586-025-03270-7 https://www.nature.com/articles/s41586-025-09602-x Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09602-xActivity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.]]> Nitsan GoldsteinAmadeus MaesHeather N. AllenTyler S. NelsonKayla A. KrugerMorgan KindelAlbert T. M. YeungNicholas K. SmithJamie R. E. CartyLavinia BocciaNiklas BlankEmily LoRachael E. VillariElla ChoErin L. MarbleMichelle AwhYasmina DumiatyMelissa J. CheeRajesh KhannaChristoph A. ThaissBradley K. TaylorAnn KennedyJ. Nicholas Betley doi:10.1038/s41586-025-09602-x Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09602-x 2025-10-08 Nature 10.1038/s41586-025-09602-x https://www.nature.com/articles/s41586-025-09602-x https://www.nature.com/articles/s41586-025-09579-7 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09579-7A systematic statistical genetics approach discovers CES drivers as hotspots of human de novo mutation and shows that clonal expansions in germline may both modulate the prevalence of disorders and lead to false-positive disease associations.]]> Vladimir SeplyarskiyMikhail A. MoldovanEvan KochPrathitha KarMatthew D. C. NevilleRaheleh RahbariShamil Sunyaev doi:10.1038/s41586-025-09579-7 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09579-7 2025-10-08 Nature 10.1038/s41586-025-09579-7 https://www.nature.com/articles/s41586-025-09579-7 https://www.nature.com/articles/s41586-025-09581-z Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09581-zStereotypes of age-related gender bias are socially distorted, as evidenced by the age gap in the representations of women and men across various media and algorithms, despite no systematic age differences in the workforce.]]> Douglas GuilbeaultSolène DelecourtBhargav Srinivasa Desikan doi:10.1038/s41586-025-09581-z Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09581-z 2025-10-08 Nature 10.1038/s41586-025-09581-z https://www.nature.com/articles/s41586-025-09581-z https://www.nature.com/articles/s41586-025-09621-8 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09621-8A full-featured 2D NOR flash memory chip realized by an atomic device to chip technology combines a superior 2D electronic device as a memory core and a powerful CMOS platform to support complex instruction control.]]> Chunsen LiuYongbo JiangBoqian ShenShengchao YuanZhenyuan CaoZhongyu BiChong WangYutong XiangTanjun WangHaoqi WuZizheng LiuYang WangShuiyuan WangPeng Zhou doi:10.1038/s41586-025-09621-8 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09621-8 2025-10-08 Nature 10.1038/s41586-025-09621-8 https://www.nature.com/articles/s41586-025-09621-8 https://www.nature.com/articles/s41586-025-09584-w Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09584-wA new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.]]> Andrew R. J. LawsonFederico AbascalPantelis A. NicolaStefanie V. LensingAmy L. RobertsGeorgios KalantzisAdrian Baez-OrtegaNatalia BrzozowskaJulia S. El-Sayed MoustafaDovile VaitkuteBelma JakupovicAyrun NessaSamuel WadgeMarc F. ÖsterdahlAnna L. PatersonDoris M. RasslRaul E. AlcantaraLaura O’NeillSara WidaaSiobhan Austin-GuestMatthew D. C. NevilleMoritz J. PrzybillaWei ChengMaria MorraLucy SykesMatthew MayhoNicole Müller-SienerthNicholas WilliamsDiana AlexanderLuke M. R. HarveyThomas ClarkeAlex ByrneJamie R. BlundellMatthew D. YoungKrishnaa T. A. MahbubaniKourosh Saeb-ParsyHilary C. MartinMichael R. StrattonPeter J. CampbellRaheleh RahbariKerrin S. SmallIñigo Martincorena doi:10.1038/s41586-025-09584-w Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09584-w 2025-10-08 Nature 10.1038/s41586-025-09584-w https://www.nature.com/articles/s41586-025-09584-w https://www.nature.com/articles/s41586-025-09603-w Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09603-wMetaGraph enables scalable indexing of large sets of DNA, RNA or protein sequences using annotated de Bruijn graphs.]]> Mikhail KarasikovHarun MustafaDaniel DanciuOleksandr KulkovMarc ZimmermannChristopher BarberGunnar RätschAndré Kahles doi:10.1038/s41586-025-09603-w Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09603-w 2025-10-08 Nature 10.1038/s41586-025-09603-w https://www.nature.com/articles/s41586-025-09603-w https://www.nature.com/articles/s41586-025-09448-3 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09448-3A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.]]> Matthew D. C. NevilleAndrew R. J. LawsonRashesh SanghviFederico AbascalMy H. PhamAlex CaganPantelis A. NicolaTetyana BayzetinovaAdrian Baez-OrtegaKirsty RobertsStefanie V. LensingSara WidaaRaul E. AlcantaraMaría Paz GarcíaSam WadgeMichael R. StrattonPeter J. CampbellKerrin SmallIñigo MartincorenaMatthew E. HurlesRaheleh Rahbari doi:10.1038/s41586-025-09448-3 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09448-3 2025-10-08 Nature 10.1038/s41586-025-09448-3 https://www.nature.com/articles/s41586-025-09448-3 https://www.nature.com/articles/s41586-025-09516-8 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09516-8A single-phase chromium–molybdenum–silicon alloy is described that exhibits compression ductility at room temperature as well as resistance to oxidation, pesting, nitridation and scale spallation at temperatures up to at least 1,100 °C.]]> Frauke HinrichsGeorg WinkensLena Katharina KramerGabriely FalcãoEwa M. HahnDaniel SchliephakeMichael Konrad EusterholzSandipan SenMathias Christian GaletzHaruyuki InuiAlexander KauffmannMartin Heilmaier doi:10.1038/s41586-025-09516-8 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09516-8 2025-10-08 Nature 10.1038/s41586-025-09516-8 https://www.nature.com/articles/s41586-025-09516-8 https://www.nature.com/articles/s41586-025-09582-y Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09582-yObservations of the shape, topography, crustal thickness and surface composition of the South Pole–Aitken impact basin on the Moon suggest a southward impact trajectory and the excavation of a discontinuous remnant magma ocean from beneath the crust.]]> Jeffrey C. Andrews-HannaWilliam F. BottkeAdrien BroquetAlexander J. EvansGabriel GowmanBrandon C. JohnsonJames T. KeaneJanette N. LevinAnanya MallikSimone MarchiSamantha A. MoruzziArkadeep RoyShigeru Wakita doi:10.1038/s41586-025-09582-y Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09582-y 2025-10-08 Nature 10.1038/s41586-025-09582-y https://www.nature.com/articles/s41586-025-09582-y https://www.nature.com/articles/s41586-025-09521-x Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09521-xSex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.]]> Ferriol CalvetRaquel Blanco Martinez-IllescasFerran MuiñosMaria TretiakovaElena S. Latorre-EstevesJeanne FredricksonMaria AndrianovaStefano PellegriniAxel Rosendahl HuberJoan Enric Ramis-ZaldivarShuyi Charlotte AnElana ThiemeBrendan F. KohrnMiguel L. GrauAbel Gonzalez-PerezNuria Lopez-BigasRosa Ana Risques doi:10.1038/s41586-025-09521-x Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09521-x 2025-10-08 Nature 10.1038/s41586-025-09521-x https://www.nature.com/articles/s41586-025-09521-x https://www.nature.com/articles/s41586-025-09578-8 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09578-8The precision of determining the phase of an optical atomic clock is increased above the standard quantum limit in a new spectroscopic method.]]> Leon ZaporskiQi LiuGustavo VelezMatthew RadzihovskyZeyang LiSimone ColomboEdwin Pedrozo-PeñafielVladan Vuletić doi:10.1038/s41586-025-09578-8 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09578-8 2025-10-08 Nature 10.1038/s41586-025-09578-8 https://www.nature.com/articles/s41586-025-09578-8 https://www.nature.com/articles/s41586-025-09585-9 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09585-9KCTD10 interacts with the DNA replication machinery and the RNA polymerase complex, inducing ubiquitination and removal of the transcription machinery in the event of co-directional transcription–replication conflicts.]]> Jake A. KloeberBin ChenGuangchao SunCharles S. KingZhiquan WangLi WangZheming WuShouhai ZhuFei ZhaoHongran QinYaobin OuyangHuaping XiaoXinyi TuJing LuYanxia JiangKuntian LuoPing YinXinyan WuRobert W. MutterJinzhou HuangZhenkun Lou doi:10.1038/s41586-025-09585-9 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09585-9 2025-10-08 Nature 10.1038/s41586-025-09585-9 https://www.nature.com/articles/s41586-025-09585-9 https://www.nature.com/articles/s41586-025-09620-9 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09620-9An optical slab waveguide with highly programmable nonlinear functionality is described, enabling the demonstration of versatile control over broadband second-harmonic generation across the spectral, spatial and spatio-spectral domains.]]> Ryotatsu YanagimotoBenjamin A. AshMandar M. SohoniMartin M. SteinYiqi ZhaoFederico PresuttiMarc JankowskiLogan G. WrightTatsuhiro OnoderaPeter L. McMahon doi:10.1038/s41586-025-09620-9 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09620-9 2025-10-08 Nature 10.1038/s41586-025-09620-9 https://www.nature.com/articles/s41586-025-09620-9 https://www.nature.com/articles/s41586-025-09604-9 Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09604-9Using a new analytical method for tracking gamma band events in mouse visual cortex, flexible encoding of visual information according to behavioural context is shown.]]> Quentin PerrenoudAntonio H. de O. FonsecaAustin AirhartJames BonannoRong MaoJessica A. Cardin doi:10.1038/s41586-025-09604-9 Nature, Published online: 2025-10-08; | doi:10.1038/s41586-025-09604-9 2025-10-08 Nature 10.1038/s41586-025-09604-9 https://www.nature.com/articles/s41586-025-09604-9 https://www.nature.com/articles/d41586-025-03222-1 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03222-1Tests of large language models reveal that they can behave in deceptive and potentially harmful ways. What does this mean for the future?]]> Matthew Hutson doi:10.1038/d41586-025-03222-1 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03222-1 2025-10-08 Nature 10.1038/d41586-025-03222-1 https://www.nature.com/articles/d41586-025-03222-1 https://www.nature.com/articles/d41586-025-02906-y Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-02906-yA large language model scans abstracts and titles for signs that an article was produced by a ‘paper mill’ company.]]> Miryam Naddaf doi:10.1038/d41586-025-02906-y Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-02906-y 2025-10-08 Nature 10.1038/d41586-025-02906-y https://www.nature.com/articles/d41586-025-02906-y https://www.nature.com/articles/d41586-025-03272-5 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03272-5The newfound ensemble of neurons could lead to therapies to treat persistent pain, which affects roughly one in five people globally.]]> Lynne Peeples doi:10.1038/d41586-025-03272-5 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03272-5 2025-10-08 Nature 10.1038/d41586-025-03272-5 https://www.nature.com/articles/d41586-025-03272-5 https://www.nature.com/articles/d41586-025-03249-4 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03249-4A voyage of self-discovery.]]> Sylvia Spruck Wrigley doi:10.1038/d41586-025-03249-4 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03249-4 2025-10-08 Nature 10.1038/d41586-025-03249-4 https://www.nature.com/articles/d41586-025-03249-4 https://www.nature.com/articles/d41586-025-03232-z Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03232-zThe genetic ancestry of domesticated barley has been mapped at high resolution, with each genome segment traced to its wild origins and the date estimated for when it entered the domesticated lineage. The findings reveal a mosaic of contributions from across western and central Asia, shaped by early cultivation and later gene flow.]]> doi:10.1038/d41586-025-03232-z Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03232-z 2025-10-08 Nature 10.1038/d41586-025-03232-z https://www.nature.com/articles/d41586-025-03232-z https://www.nature.com/articles/d41586-025-03195-1 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03195-1Susumu Kitagawa, Richard Robson and Omar Yaghi pioneered the creation of metal–organic frameworks, which can capture and store molecules such as carbon dioxide.]]> Davide CastelvecchiMiryam Naddaf doi:10.1038/d41586-025-03195-1 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03195-1 2025-10-08 Nature 10.1038/d41586-025-03195-1 https://www.nature.com/articles/d41586-025-03195-1 https://www.nature.com/articles/d41586-025-02975-z Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-02975-zScientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.]]> Jian Carrot-Zhang doi:10.1038/d41586-025-02975-z Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-02975-z 2025-10-08 Nature 10.1038/d41586-025-02975-z https://www.nature.com/articles/d41586-025-02975-z https://www.nature.com/articles/d41586-025-03235-w Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03235-wThe light frequency associated with changes in the energy state of atoms can be used to define the ticking of high-precision optical clocks. Experiments with ytterbium atoms have further enhanced the clocks’ precision by using a quantum amplification technique.]]> doi:10.1038/d41586-025-03235-w Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03235-w 2025-10-08 Nature 10.1038/d41586-025-03235-w https://www.nature.com/articles/d41586-025-03235-w https://www.nature.com/articles/d41586-025-02973-1 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-02973-1An approach for making nanoscale high-entropy alloys using liquid metal provides much-needed control over the structure and composition of these remarkable materials.]]> Yunqing KangYusuke Yamauchi doi:10.1038/d41586-025-02973-1 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-02973-1 2025-10-08 Nature 10.1038/d41586-025-02973-1 https://www.nature.com/articles/d41586-025-02973-1 https://www.nature.com/articles/d41586-025-03219-w Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03219-wMetaGraph compresses vast data archives into a search engine for scientists, opening up new frontiers of biological discovery.]]> Elie Dolgin doi:10.1038/d41586-025-03219-w Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03219-w 2025-10-08 Nature 10.1038/d41586-025-03219-w https://www.nature.com/articles/d41586-025-03219-w https://www.nature.com/articles/d41586-025-03320-0 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03320-0This year’s Nobel Prize in Chemistry goes to the three chemists behind the world’s most porous solid materials. Plus, the risks of AI models that scheme and lie, and a warning from six former US surgeons general about the nation’s public health system.]]> Flora Graham doi:10.1038/d41586-025-03320-0 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03320-0 2025-10-08 Nature 10.1038/d41586-025-03320-0 https://www.nature.com/articles/d41586-025-03320-0 https://www.nature.com/articles/d41586-025-03238-7 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-03238-7Close cooperation in flight between vertically stacked multirotor drones is widely regarded as dangerous, because there is persistent and intense ‘downwash’ interference. A ‘flying toolbox’ has been developed that achieves high-accuracy docking despite the downwash, enabling mid-air tool exchanges and unlocking diverse aerial manipulation tasks.]]> doi:10.1038/d41586-025-03238-7 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-03238-7 2025-10-08 Nature 10.1038/d41586-025-03238-7 https://www.nature.com/articles/d41586-025-03238-7 https://www.nature.com/articles/d41586-025-02594-8 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-02594-8Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting, a condition called cachexia.]]> Kerstin HaaseMariam Jamal-Hanjani doi:10.1038/d41586-025-02594-8 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-02594-8 2025-10-08 Nature 10.1038/d41586-025-02594-8 https://www.nature.com/articles/d41586-025-02594-8 https://www.nature.com/articles/d41586-025-02974-0 Nature, Published online: 08 October 2025; doi:10.1038/d41586-025-02974-0A big-data analysis shows that online content represents men as older than women in the same occupations and social roles, and that AI reproduces these warped presentations.]]> Ana Macanovic doi:10.1038/d41586-025-02974-0 Nature, Published online: 2025-10-08; | doi:10.1038/d41586-025-02974-0 2025-10-08 Nature 10.1038/d41586-025-02974-0 https://www.nature.com/articles/d41586-025-02974-0 https://www.nature.com/articles/d41586-025-03107-3 Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03107-3Insect biodiversity monitoring must be expanded]]> Kris A. G. WyckhuysYves BassetOwen T. Lewis doi:10.1038/d41586-025-03107-3 Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03107-3 2025-10-07 Nature 10.1038/d41586-025-03107-3 https://www.nature.com/articles/d41586-025-03107-3 https://www.nature.com/articles/d41586-025-03277-0 Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03277-0Stop destructive fishing in marine protected areas]]> Jenna Sullivan-StackEstradivariElizabeth P. PikeFabrice Stephenson doi:10.1038/d41586-025-03277-0 Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03277-0 2025-10-07 Nature 10.1038/d41586-025-03277-0 https://www.nature.com/articles/d41586-025-03277-0 https://www.nature.com/articles/d41586-025-02978-w Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-02978-wLively scientific debates found in correspondence from 1916 to 1918, and Saint Patrick’s snake-banishment skills are called into question in this week’s pick from the Nature archive.]]> doi:10.1038/d41586-025-02978-w Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-02978-w 2025-10-07 Nature 10.1038/d41586-025-02978-w https://www.nature.com/articles/d41586-025-02978-w https://www.nature.com/articles/d41586-025-03278-z Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03278-zMicrobe discovery holds promise for sustainable biotechnology]]> Jie LiShuwen LiuHao SongShiming Ding doi:10.1038/d41586-025-03278-z Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03278-z 2025-10-07 Nature 10.1038/d41586-025-03278-z https://www.nature.com/articles/d41586-025-03278-z https://www.nature.com/articles/d41586-025-03276-1 Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03276-1Incentives accelerate progress on open access in Spain]]> Wenceslao Arroyo-MachadoDaniel Torres-Salinas doi:10.1038/d41586-025-03276-1 Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03276-1 2025-10-07 Nature 10.1038/d41586-025-03276-1 https://www.nature.com/articles/d41586-025-03276-1 https://www.nature.com/articles/d41586-025-03194-2 Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03194-2John Clarke, Michel Devoret and John Martinis discovered quantum physics on a macroscopic scale, paving the way for quantum computing.]]> Elizabeth GibneyDavide Castelvecchi doi:10.1038/d41586-025-03194-2 Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03194-2 2025-10-07 Nature 10.1038/d41586-025-03194-2 https://www.nature.com/articles/d41586-025-03194-2 https://www.nature.com/articles/d41586-025-03218-x Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03218-xData reveal how the global challenge to reduce deaths and infections from drug-resistant bacteria is not going according to plan.]]> Katie Kavanagh doi:10.1038/d41586-025-03218-x Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03218-x 2025-10-07 Nature 10.1038/d41586-025-03218-x https://www.nature.com/articles/d41586-025-03218-x https://www.nature.com/articles/d41586-025-03287-y Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03287-yRegulatory T cells, which help to dampen inflammation, are being used in clinical trials against ailments such as rheumatoid arthritis.]]> Rachel Fieldhouse doi:10.1038/d41586-025-03287-y Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03287-y 2025-10-07 Nature 10.1038/d41586-025-03287-y https://www.nature.com/articles/d41586-025-03287-y https://www.nature.com/articles/d41586-025-03228-9 Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03228-9Open and adaptable artificial-intelligence models are crucial for scientific progress, but robust safeguards against their misuse are still nascent.]]> Yarin GalStephen Casper doi:10.1038/d41586-025-03228-9 Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03228-9 2025-10-07 Nature 10.1038/d41586-025-03228-9 https://www.nature.com/articles/d41586-025-03228-9 https://www.nature.com/articles/d41586-025-03221-2 Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03221-2It is time to sound the alarm as the EU’s research priorities face an unprecedented degree of political interference.]]> doi:10.1038/d41586-025-03221-2 Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03221-2 2025-10-07 Nature 10.1038/d41586-025-03221-2 https://www.nature.com/articles/d41586-025-03221-2 https://www.nature.com/articles/d41586-025-03292-1 Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03292-1Three researchers share this year’s Nobel Prize in Physics for demonstrating that quantum tunnelling could be observed in a special type of circuit. Plus, neurons can pass messages through tiny tubes and what a doughnut can tell us about the path to true prosperity.]]> Flora Graham doi:10.1038/d41586-025-03292-1 Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03292-1 2025-10-07 Nature 10.1038/d41586-025-03292-1 https://www.nature.com/articles/d41586-025-03292-1 https://www.nature.com/articles/d41586-025-03196-0 Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03196-0Scientists, research institutions, funders, libraries and publishers must all improve software practices.]]> Roberto Di CosmoSabrina GrangerKonrad HinsenNicolas JullienDaniel Le BerreViolaine LouvetCamille MaumetClémentine MauriceRaphaël MonatNicolas P. Rougier doi:10.1038/d41586-025-03196-0 Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03196-0 2025-10-07 Nature 10.1038/d41586-025-03196-0 https://www.nature.com/articles/d41586-025-03196-0 https://www.nature.com/articles/d41586-025-03217-y Nature, Published online: 07 October 2025; doi:10.1038/d41586-025-03217-yThe future of science will be written by humans and machines together. Awards should reflect that reality.]]> Dashun Wang doi:10.1038/d41586-025-03217-y Nature, Published online: 2025-10-07; | doi:10.1038/d41586-025-03217-y 2025-10-07 Nature 10.1038/d41586-025-03217-y https://www.nature.com/articles/d41586-025-03217-y https://www.nature.com/articles/d41586-025-03231-0 Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03231-0Environmental-humanities researcher Jenia Mukherjee uncovers the complex relationship between people, canals and wetlands in Kolkata, India.]]> Nikki Forrester doi:10.1038/d41586-025-03231-0 Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03231-0 2025-10-06 Nature 10.1038/d41586-025-03231-0 https://www.nature.com/articles/d41586-025-03231-0 https://www.nature.com/articles/d41586-025-03229-8 Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03229-8Nature’s survey of PhD candidates reveals hard-won wisdom on choosing supervisors, managing mental health and surviving academic culture.]]> Linda Nordling doi:10.1038/d41586-025-03229-8 Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03229-8 2025-10-06 Nature 10.1038/d41586-025-03229-8 https://www.nature.com/articles/d41586-025-03229-8 https://www.nature.com/articles/d41586-025-03227-w Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03227-wShe was a tireless advocate for conservation, the welfare of captive chimpanzees and the protection of habitats.]]> Richard Wrangham doi:10.1038/d41586-025-03227-w Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03227-w 2025-10-06 Nature 10.1038/d41586-025-03227-w https://www.nature.com/articles/d41586-025-03227-w https://www.nature.com/articles/d41586-025-03286-z Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03286-zMeet the winners of this year’s Nobel Prize in Physiology or Medicine. Plus, creative hobbies could slow brain ageing at the molecular level and a visit to a sewage-filtering wetland.]]> Flora Graham doi:10.1038/d41586-025-03286-z Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03286-z 2025-10-06 Nature 10.1038/d41586-025-03286-z https://www.nature.com/articles/d41586-025-03286-z https://www.nature.com/articles/d41586-025-03225-y Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03225-yAn optimistic take on the state of the longevity field provides hope for treating a range of ageing-related diseases — but feels at odds with the current shape of US research.]]> Coleen T. Murphy doi:10.1038/d41586-025-03225-y Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03225-y 2025-10-06 Nature 10.1038/d41586-025-03225-y https://www.nature.com/articles/d41586-025-03225-y https://www.nature.com/articles/d41586-025-03223-0 Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03223-0Other researchers question whether autonomous AI scientists are possible or even desirable.]]> Jenna Ahart doi:10.1038/d41586-025-03223-0 Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03223-0 2025-10-06 Nature 10.1038/d41586-025-03223-0 https://www.nature.com/articles/d41586-025-03223-0 https://www.nature.com/articles/d41586-025-02669-6 Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-02669-6Struggling to agree on a meaningful moniker for your start-up? This firm’s founders turned to their employees for inspiration.]]> Jacqui Thornton doi:10.1038/d41586-025-02669-6 Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-02669-6 2025-10-06 Nature 10.1038/d41586-025-02669-6 https://www.nature.com/articles/d41586-025-02669-6 https://www.nature.com/articles/d41586-025-03193-3 Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03193-3Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.]]> Miryam NaddafElizabeth Gibney doi:10.1038/d41586-025-03193-3 Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03193-3 2025-10-06 Nature 10.1038/d41586-025-03193-3 https://www.nature.com/articles/d41586-025-03193-3 https://www.nature.com/articles/d41586-025-03181-7 Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03181-7Medical specialists, wary of the guidance provided by Trump’s team, offer up their own advice independently of the government.]]> Mariana Lenharo doi:10.1038/d41586-025-03181-7 Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03181-7 2025-10-06 Nature 10.1038/d41586-025-03181-7 https://www.nature.com/articles/d41586-025-03181-7 https://www.nature.com/articles/d41586-025-03224-z Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03224-zGreening the global economy does not have to be done through unjust fuel extraction; societies can choose fairer paths to net-zero emissions.]]> Sophia Kalantzakos doi:10.1038/d41586-025-03224-z Nature, Published online: 2025-10-06; | doi:10.1038/d41586-025-03224-z 2025-10-06 Nature 10.1038/d41586-025-03224-z https://www.nature.com/articles/d41586-025-03224-z https://www.nature.com/articles/s41586-025-09682-9 Nature, Published online: 03 October 2025; doi:10.1038/s41586-025-09682-9Author Correction: Ribonucleotide incorporation into mitochondrial DNA drives inflammation]]> Amir BahatDusanka MilenkovicEileen CorsMabel BarnettSadig NiftullayevAthanasios KatsalifisMarc SchwillPetra KirschnerThomas MacVicarPatrick GiavaliscoLouise JenningerAnders R. ClausenVincent PaupeJulien PrudentNils-Göran LarssonManuel RoggChristoph SchellIsabella MuylaertErik LarssonHendrik NolteMaria FalkenbergThomas Langer doi:10.1038/s41586-025-09682-9 Nature, Published online: 2025-10-03; | doi:10.1038/s41586-025-09682-9 2025-10-03 Nature 10.1038/s41586-025-09682-9 https://www.nature.com/articles/s41586-025-09682-9 https://www.nature.com/articles/d41586-025-03248-5 Nature, Published online: 03 October 2025; doi:10.1038/d41586-025-03248-5Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.]]> Rachel Fieldhouse doi:10.1038/d41586-025-03248-5 Nature, Published online: 2025-10-03; | doi:10.1038/d41586-025-03248-5 2025-10-03 Nature 10.1038/d41586-025-03248-5 https://www.nature.com/articles/d41586-025-03248-5 https://www.nature.com/articles/d41586-025-03208-z Nature, Published online: 03 October 2025; doi:10.1038/d41586-025-03208-zCha 1107-7626 is devouring matter during its solo drift across the Galaxy.]]> doi:10.1038/d41586-025-03208-z Nature, Published online: 2025-10-03; | doi:10.1038/d41586-025-03208-z 2025-10-03 Nature 10.1038/d41586-025-03208-z https://www.nature.com/articles/d41586-025-03208-z https://www.nature.com/articles/d41586-025-03226-x Nature, Published online: 03 October 2025; doi:10.1038/d41586-025-03226-xAndrew Robinson reviews five of the best science picks.]]> Andrew Robinson doi:10.1038/d41586-025-03226-x Nature, Published online: 2025-10-03; | doi:10.1038/d41586-025-03226-x 2025-10-03 Nature 10.1038/d41586-025-03226-x https://www.nature.com/articles/d41586-025-03226-x https://www.nature.com/articles/s41586-025-09587-7 Nature, Published online: 03 October 2025; doi:10.1038/s41586-025-09587-7The release of triplet or singlet oxygen is governed by individual Marcus normal and inverted region behaviour.]]> Soumyadip MondalHuyen T. K. NguyenRobert HauschildStefan A. Freunberger doi:10.1038/s41586-025-09587-7 Nature, Published online: 2025-10-03; | doi:10.1038/s41586-025-09587-7 2025-10-03 Nature 10.1038/s41586-025-09587-7 https://www.nature.com/articles/s41586-025-09587-7