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Rate of infusion - Wikipedia Jump to content

Rate of infusion

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In pharmacokinetics, the rate of infusion (or dosing rate) refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective.

Abbreviations include K_in,^[1] K₀,^[2] or R₀.

It can be calculated as the steady-state concentration in the plasma multiplied by the clearance:

$\textstyle K_{in}=C_{ss}\cdot CL$

References

^ "Cp vs time - iv infusion". Archived from the original on 2008-04-25.
^ "Chapter 15.2 - Continuous IV Infusion - Steady State". Archived from the original on 2013-10-22.

Ligand (biochemistry)

Excitatory	Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist

Inhibitory	Antagonist Competitive antagonist Irreversible antagonist Physiological antagonist Inverse agonist Enzyme inhibitor

Pharmacodynamics

Activity at receptor	Mechanism of action Mode of action Binding Receptor (biochemistry) Desensitization (medicine)

Other effects of ligand	Selectivity (Binding, Functional) Pleiotropy (drugs) Non-specific effect of vaccines Adverse effect Toxicity (Neurotoxicity)

Analysis	Dose–response relationship Hill equation (biochemistry) Schild plot Del Castillo Katz model Cheng-Prussoff Equation Methods (Organ bath, Ligand binding assay, Patch clamp)

Metrics	Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Pharmacokinetics

Metrics	Loading dose Volume of distribution (Initial) Rate of infusion Onset of action Biological half-life Plasma protein binding Bioavailability

LADME	(L)ADME: (Liberation) Absorption Distribution Metabolism Excretion (Clearance)

Related
fields

Neuroscience and psychology	Neuropsychopharmacology Neuropharmacology Psychopharmacology Electrophysiology

Medicine	Clinical pharmacology Pharmacy Medicinal chemistry Pharmacoepidemiology

Biochemistry and genetics	Pharmacoinformatics Pharmacogenetics Pharmacogenomics

Toxicology	Pharmacotoxicology Neurotoxicology

Drug discovery	Classical pharmacology Reverse pharmacology

Other

Coinduction (anesthetics)

Combination therapy

Functional analog (chemistry)

Polypharmacology

WHO list of essential medicines

Tolerance and resistance	Drug tolerance Tachyphylaxis Drug resistance Antibiotic resistance Multiple drug resistance

Antimicrobial pharmacology	Antimicrobial pharmacodynamics Minimum inhibitory concentration Bacteriostatic Minimum bactericidal concentration Bactericide

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