2C-CPE

2C-CPE
Identifiers
	IUPAC name 2-(4-cyclopentyl-2,5-dimethoxyphenyl)ethanamine;
PubChem CID	169149436;
Chemical and physical data
Formula	C15H23NO2
Molar mass	249.354 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC(=C(C=C1CCN)OC)C2CCCC2;
	InChI InChI=1S/C15H23NO2/c1-17-14-10-13(11-5-3-4-6-11)15(18-2)9-12(14)7-8-16/h9-11H,3-8,16H2,1-2H3; Key:GIYHLPFOZWFVHO-UHFFFAOYSA-N;

2C-CPE is a designer drug from the substituted phenethylamine family, which was first synthesised by Josh Hartsel and colleagues in 2024. It is a moderately potent agonist at the serotonin receptor 5-HT_2A in vitro, with a binding affinity (K_i) of 134 nM, slightly weaker than the related cyclopropyl compound 2C-CP. It is not known to have been tested in humans or animals.^[1]

References

^ Varty GB, Canal CE, Mueller TA, Hartsel JA, Tyagi R, Avery K, Morgan ME, Reichelt AC, Pathare P, Stang E, Palfreyman MG, Nivorozhkin A (April 2024). "Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT₂ Receptor Agonist". Journal of Medicinal Chemistry. 67 (8): 6144–6188. doi:10.1021/acs.jmedchem.3c01961. PMID 38593423.

This hallucinogen-related article is a stub. You can help Wikipedia by expanding it.

[1] Varty GB, Canal CE, Mueller TA, Hartsel JA, Tyagi R, Avery K, Morgan ME, Reichelt AC, Pathare P, Stang E, Palfreyman MG, Nivorozhkin A (April 2024). "Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT₂ Receptor Agonist". Journal of Medicinal Chemistry. 67 (8): 6144–6188. doi:10.1021/acs.jmedchem.3c01961. PMID 38593423.

[1]

See also

References